Nerve Fibres Containing Gastrin-Releasing Peptide around Pial Vessels

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gastrin releasing peptide and pentagastrin

Accepted for publication 9 November 1995 Abstract Background-Patients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear. Aim-To discover if gastric acid hypersecretion in patients with DU is caused by Hpylori. Patients and methods-BAO, gastrin releasing peptide (GRP), and pentagastrin stimulate...

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Molecular basis of the selectivity of gastrin-releasing peptide receptor for gastrin-releasing peptide.

The mammalian bombesin peptides [gastrin-releasing peptide (GRP) and neuromedin B (NMB)] are important in numerous biological and pathological processes. These effects are mediated by the heptahelical GRP receptor (GRPR) and NMB receptor (NMBR). GRP has high affinity for GRPR and lower affinity for NMBR. Almost nothing is known about the molecular basis for the selectivity of GRP. To address th...

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Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours.

AIMS To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours. METHODS Twenty six carcinoid tumours from the stomach, small intestine, appendix, and colorectum were investigated by immunohistochemistry for GRP and GRPR. RESULTS GRP was detected in nine of 19 tumours and GRPR in 22 of 26. Coexpression of bot...

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Overexpression of Gastrin-Releasing Peptide Receptors in Tumor-Associated Blood Vessels of Human Ovarian Neoplasms

BACKGROUND Peptide receptors, overexpressed in specific cancers, represent new diagnostic and therapeutic targets. In this study, receptors for the gastrin-releasing peptide (GRP), and other members of the bombesin-family of peptides, were evaluated in ovarian neoplasms. METHODS 75 primary, secondary and metastatic ovarian tumors were investigated for their bombesin-receptor subtype expressio...

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Distribution of gastrin-releasing peptide/bombesin-like immunoreactive cell bodies and fibres in the brainstem of the cat.

Using an indirect immunoperoxidase technique, the location of gastrin-releasing/bombesin-like immunoreactive fibres and cell bodies in the cat brainstem was studied. A moderate or low density of immunoreactive cell bodies was observed in the nucleus of the brachium of the inferior colliculus, pericentral nucleus of the inferior colliculus, ventral nucleus of the lateral lemniscus and in the ext...

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ژورنال

عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism

سال: 1983

ISSN: 0271-678X,1559-7016

DOI: 10.1038/jcbfm.1983.56